Clinical (Foreground) questions:
Exploratory quesitons:
PICO Framework
PICOS
P Patient Population
I Intervention OR Exposure
C Comparator Group
O Outcome OR Endpoint
S Study Design
PICOT
P Patient Population
I Intervention OR Exposure
C Comparison
O Outcome OR Endpoint
T Time
WWH
ECLIPSE
PEO
SPICE
SPIDER
PICo
SPIDER