Most clinical encounters lead to a need for information. The first step in EBM is to translate the need for information into a question that can be answered by clinical research.
There are "foreground" questions and "background" questions.
Background questions:
Foreground questions:
PICO
P Patient Population
I Intervention OR Exposure
C Comparator Group
O Outcome OR Endpoint
S Study Design
PEO
SPICE
PICOC
WWH