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University Library, University of Illinois at Urbana-Champaign

Evidence-Based Medicine (EBM)

Appraisal of Diagnosis Study


  • Was there a blind comparison with reference standard? (Gold Standard)
  • Was there a broad representation of patients?
  • Were both tests given to all patients?


  • Assess Liklihood ratios
  • Is the test reproducible?
  • Will patient care be better using this test?

BMJ Best Practice

There are many checklists available for the assessment and critical appraisal of diagnostic test studies, as reporting is frequently inadequate
[1][2] However, they all include some variation of three critical questions;[2][3] these are:

  • Is this study valid?
  • Does the diagnostic test under assessment accurately distinguish between people who do and do not have the specific disorder?
  • Can I apply this valid, accurate diagnostic test to a specific patient?