EndNote is software that allows you to keep track of your citations, organize them into folders, and create references and bibliographies in your papers.

You can:

• Create your own searchable library of citations, often with links to full text or pdfs of articles
• Search library databases (including the library catalog) from within EndNote, and import citations
• Or search directly within the databases and export the citations you want
• Use EndNote to easily format references and bibliographies in your papers to conform to styles used by hundreds of different journals

EndNote is similar to Refworks and Zotero, but it allows you to produce bibliographies in a greater number of citation styles and allows greater customization. It is particularly popular in the sciences.

Unlike these web-based applications, EndNote is not free, and requires download and installation. You can download a 30-day trial version from the Endnote website, or buy it from the University of Illinois WebStore.  

More details are available on this on the EndNote LibGuide.